July 18, 2026Wellness

How Amino Acids, Mg, Vit B6 calms nervous system

There are multiple amino acids and vitamins which calm down the nervous system, helping in sleep restoration and relaxation

Importance of essential amino acids in strength training

Any kind of training and exercise is mainly aimed at ameliorating performances. From training for performing better or recovering from illness, our common nutritional needs do not suffice.

For better nutrition, amino acids in their desired quantities are very important as an abundant availability of these essential amino acids along with oxygen is suitable for ATP production. This further accelerates protein synthesis.

Why exercise increase our nutritional needs?

This can be explained in these following steps:

• ATP production is mainly dependent on mitochondria efficiency which requires activation of mitochondrial biogenesis and increased oxygen supply

• This energy reduction by mitochondria controls protein synthesis since any peptide bond requires 4 ATPs and this ATP production creates huge amounts of reactive oxygen species.

• The linking factor between all these scientific parameters are the essential amino acids which help in protein synthesis epigenetically activating mitochondrial biogenesis, production and consumption of ATS and ROS production (Dioaguardi).

Apart from training, amino acids are also needed for calming you down for your recovery making you ready the next day.

Importance of amino acids in brain health

Amino acids play an important role in brain functioning and metabolism. Some amino acids help in the formation of neurotransmitters in the nervous system like tyrosine for catecholamines, Histidine – histamine, and tryptophan for serotonin (Bon, Maksimovich and Burak, 2023). Another study claims that tryptophan along with tyrosine, histidine and arginine is used by our brain for the synthesis of neurotransmitters as well as neuromodulators.  

Why are L theanine, L tryptophan used?

According to current research, there is an established association in the changes of protein as well as carbohydrate intake along with changes in behavior. Tryptophan has been linked previously with changes in a variety of behavioral patterns, one of them being self-reported mental fatigue. Sold as an natural sleep aid previously, tryptophan is related to the activation of serotonin in mood regulation especially depression.

As a naturally occurring structural analogue of glutamate, L theanine compete with receptors for glutamate able to pass the blood brain barrier for exerting its relaxation effect. Due to its similar structure in theanine, it acts as a regulator in neurodegeneration. Moreover, it is non mutagenic, non-carcinogenic and well tolerated in mammal cells. Predominantly found in tea, L theanine further has anti- anxiolytic effects which also protects neurons against neurotoxic effects improving cognition, mood while promoting relaxation. It exhibits pharmacological effects on brain through modulating neurotransmitters which eventually reduces glutamate release increasing inhibitory neurotransmitter GABA levels enhancing glycine as well as dopamine release (Wang et al., 2022).

In animal preclinical studies, L theanine is considered as a neuroprotective as well as cognitive enhancing agent. It has also been involved in enhibiting anti-stress or antidepressant like effects associated with the increase of brain derived neurotrophic factors in the hippocampus.

In one such study, the stress related symptoms like depression, anxiety trait as well as sleep scores have decreased and cognitive scores have improved after 4 weeks of L theanine administration indicating that it might be a suitable ingredient for mental improvement condition in a healthy population (Hidese et al., 2019).

What is Vitamin B6 and what are its effects on health

Vitamin B6 which is inclusive of pyridoxine , pyridoxal, pyridoxamine along with phosphorylated forms serves as a major cofactor in amino acid metabolism , neurotransmitter biosystem biosynthesis as well as immune regulation. It is also involved in the synthesis of neurotransmitters like GABA, serotonin as well as Dopamine. Vitamin B6 also has certain stress reducing properties like hypotensive effects which might reduce the physiological consequences of corticosteroid release. Vitamin B 6 deficiency is mainly linked to neurological dysregulation, renal impairment and autoimmune disorders (Wu et al., 2025).

Magnesium's role in calming the nervous system

In one study, Magnesium status has been shown to be linked with anxiety, depression as well as mood changes. During stress, corticosteroids as well as catecholamines are released where prolonged release of these stress associated hormones cause a substantial loss of magnesium from body stores. Another cross-sectional study with 3000 individuals further confirms Vitamin B6 with an decreased risk of anxiety as well as depression in a cross-sectional study (Kafeshani et al., 2020). There has been further supporting growing body of evidence which supports in improving stress related mental health while the addition of Vitamin B6 is also assumed to offer additional benefits in such populations (Noah et al., 2021).

Magnesium and Vitamin B6 together- According to some studies, they work together in optimizing the body’s absorption as well as utilization of essential nutrients. In combination they help in mood enhancement, hearth health, brain function as well as energy stability.

Combination of all ingredients for sleep restoration and mood enhancement

By now, we have understood the fact all the abovementioned factors are important for calming down our nervous system.

What if all of them are combined together?

We get a powerful mood enhancing and sleep restoring stack with a thoughtful formula which does not rely on a single ingredient for its efficient working.

Magnesium, especially in its chelated form helps in the regulation of NMDA receptor excitability supporting GABA signaling, where the glycinate form is gentle on the GI tract and well absorbed.

Amino acids like L theanine and Tryptophan help in sleeping better by calming the brain having an additional synergistic effect on sleep, improving the overall sleep quality especially if combined with magnesium. Furthermore, animal studies have shown that taking both supplements would improve sleep by boosting the slow brain waves helping in relaxation by increasing hormones like GABA which support calmness and relaxation.

Vitamin B6 ensures all of the above elements are working well bound and functional, acting as an essential co-factor for serotonin and GABA synthesis.

How Does Newedge Triple Magnesium Complex shines in formulation?

Newedge Triple magnesium complex has a healthy stack of all these ingredients. Magnesium is present in 3 powerful complexes which ensure higher absorption and better bioavailability of Magnesium for better functioning. Similarly, it has all other ingredients like Vitamin B6,  L tryptophan and L theanine further having a calming effect on the nervous system, promoting restorative sleep, relaxation.

References

Dioaguardi, Francesco Saverio. “Use of Amino Acids as Supplements for Matching Nutrition, Training, and Rehabilitation—Focusing on Some Questions.” Nutrients, vol. 17, no. 16, 18 Aug. 2025, p. 2667, 10.3390/nu17162667. Accessed 18 July 2026.

Hidese, Shinsuke, et al. “Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial.” Nutrients, vol. 11, no. 10, 3 Oct. 2019, p. 2362, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6836118/, 10.3390/nu11102362. Accessed 18 July 2026.

Kafeshani, Marzi, et al. “Higher Vitamin B6 Intake Is Associated with Lower Depression and Anxiety Risk in Women but Not in Men: A Large Cross-Sectional Study.” International Journal for Vitamin and Nutrition Research. Internationale Zeitschrift Fur Vitamin- Und Ernahrungsforschung. Journal International De Vitaminologie Et De Nutrition, vol. 90, no. 5–6, 1 Oct. 2020, pp. 484–492, https://pubmed.ncbi.nlm.nih.gov/31188081/, 10.1024/0300-9831/a000589. Accessed 18 July 2026.

Noah, Lionel, et al. “Effect of Magnesium and Vitamin B6 Supplementation on Mental Health and Quality of Life in Stressed Healthy Adults: Post‐Hoc Analysis of a Randomised Controlled Trial.” Stress and Health, vol. 37, no. 5, 6 May 2021, 10.1002/smi.3051.

Wang, Liwen, et al. “How Does the Tea L-Theanine Buffer Stress and Anxiety.” Food Science and Human Wellness, vol. 11, no. 3, 1 May 2022, pp. 467–475, https://www.sciencedirect.com/science/article/pii/S2213453021001324, 10.1016/j.fshw.2021.12.004. Accessed 18 July 2026.

Wu, Ying, et al. “Vitamin B6 Form Produced by Lactobacillus Induces Metabolic Disorder and Suppresses Multi-Pathogenic Bacteria.” Communications Biology, vol. 9, no. 1, 20 Dec. 2025, https://www.nature.com/articles/s42003-025-09348-2, 10.1038/s42003-025-09348-2. Accessed 18 July 2026.