March 3, 2026Wellness

The Supplemental Solution to Stress & Anxiety 24*7

How stress mounts up at the last moment - Ashwagandha and its role in stress control 

Highest bioavailability with maximized efficacy- power of Shoden Ashwagandha

At Newedge Healthcare, we blend traditional wisdom with scientific accuracy formulating products with proven health benefits and long-lasting physiological improvement. Our hero ingredient, Shoden Ashwagandha has a unique 35% of withanolides, the main bioactive compound, clinically tested for improving sleep patterns, stress , cortisol reduction, and immunity improvement. Among other Ashwagandha extracts like KSM 66 and Sensoril, Shoden proves to be the most competent extract with 7X potency and bioavailability.

Newedge Optimised Ashwagandha & Holybasil Complex uses Shoden Ashwagandha, a clinically tested as well as purified Ashwagandha extract with 35% withanolides, highest percentage present in Ashwagandha extracts compared to other market competitors. The uniqueness of this extract lies in the fact that a proprietary extraction process is used for providing an Ashwagandha adaptogenic extract with highest potency even at a low dose of 60 mg. To understand better, withanolides are the primary bio-active components present in Ashwagandha which is enriched as well as optimised to industrial standards for high efficacy. This percentage increases the potency of the product upto 7 times more than standard Ashwagandha extracts harnessing the complete power of the key bioactive present in the roots and leaves of the plant.

Herbal stress relief

Shoden Ashwagandha has been clinically tested and tried for its effects on stress management in human subjects. One of the primary outcomes of a randomized double blinded placebo-controlled study highlights the effects of Shoden 60 mg as well as 120 mg having 35% withanolides in anxiety disorder patients with high stress levels prominent in Hamilton Anxiety Rating Scale (HAM-A). Both AE60 and AE120 have significantly reduced the HAM-A by 59% (Deo Nidhi Mishra and Kumar, 2024). Apart from this experiment Shoden is also supported by multiple clinical trials and studies confirming its role in sleep improvement and increased physical performance.

Fig 2: Relative treatment effect (RTE) plot for the different outcome variables 1. Hamilton Anxiety scale B. Serum cortisol C. Serum testosterone in males D. Perceived Stress scale E. Patient Global impression of Change F. Clinical Global Scale severity

Shoden ashwagandha for sleep: Effect on sleep quality

In another human clinical study, which is a double blinded randomized placebo-controlled trail in 150 participants, there has been no case of dropout due to any adverse reaction. Furthermore a 72% rise in the self-reported sleep quality has been found in comparison with the 29% improvement in the placebo group (Deshpande et al.) Sleep quality is also measured by parameters like non restorative sleep which was also increased here. Furthermore, improvement in sleep efficiency, total sleep time as well as sleep latency and the wake after sleep was seen after 6 weeks.

Fig 3: Increase in Restorative sleep by 72% after use of Ashwagandha as compared to placebo (29%) in 6 weeks

Improve your immunity with Shoden Ashwagandha

Shoden Ashwagandha claims to have a prominent impact in the immouno-modulatory functions of humans as well which would improve your immunity. According to published data from the journal of clinical medicine, a randomized, controlled clinical study in 25 men and women in the age group 45- 72 have been conducted where patients randomly received placebo/ Shoden for a month. From the results it has been found that 60 mg of Ashwagandha with 35% standardized withanolide extracts has positively impacted and upregulated the adaptive immune systems in the healthy subjects assessed by measurement of cytokines B, T cells, NK cells and its impact on immunoglobulins like IgA, IgGs have been profound, improving overall patient immune profile. Researchers claim that Ashwagandha in this chemical form has immune stimulatory activities and is a valuable addition in the category of immunity boosting herbal supplements (Tharakan et al.).

Fig 4: Box plot presentation showing the difference in participants treated with Ashwagandha vs placebo considering baseline and day 30. (a) Comparison of immunoglobulin level (mg/dL) in serum (n = 12/group) for the study period (day 0–30) (b) Comparison of mean difference (bias) and confidence intervals for the bias of cytokine level (pg/mL) in serum (n = 12/group) for the study period (day 0–30). (c) Comparison of mean difference (bias) and confidence intervals for the bias of T cells (CD3+ CD4+, CD8+), B cells (CD19+), CD45+, and NK absolute cell counts (cells/µL) in whole blood (n = 12/group) for the study period (day 0–30). * Significant at p < 0.05. ** Significant at p < 0.01. • Not significant (p > 0.05).

Overall, considering multiple experimental studies and clinical trials made on Shoden Ashwagandha, the following inferences can be made

Ashwagandha extracts with 35% withanolide glycosides at 60 and 120 mg reduces serum cortisol and simultaneously increases total testosterone.
Withanolide glycosides are exceptional for their quality alongside quantity with higher bioavailability than all other types of withanolides.
Shoden have been confirmed to regulate the hypothalamus- pituitary- adrenal axis thus reducing cortisol and increasing the GAMA neurotransmitters for relaxation.
Leaf and root extract of Ashwagandha standardized with withanolide glycosides possess important immuno-stimulatory properties, causing proliferation of CD4+/CD8+ and increasing CD3+/CD19+/CD45+

Difference between various Ashwagandha extracts available in the market: Why Shoden is the purest and most potent Ashwagandha extract

Ashwagandha or Withania somnifera extracts as already discussed are very popular adaptogens mentioned in ancient Ayurvedic scriptures and the key bio actives directly associated with Ashwagandha benefits are withanolides. Till date over 35 various withanolides have been extracted from the Ashwagandha plant but mostly withaferin A, withanoside V, withanolides A and B are used due to their excellent bioavailability. Here, we would understand the basic difference between the most common proprietary extracts of Ashwagandha considering their sources, processing nature as well as concentration or differences in purity of the bio-actives.

KSM-66 Ashwagandha

KSM Ashwagandha is a branded, broad spectrum Ashwagandha extract where only root extracts are used without any leaf extract incorporation, making it a product with highest root extracts available in the market. KSM-66 is known for its intensive manufacturing process going through the most extensive safety assessments in the nutraceuticals market. Known having gold standard assessments, it has evaluation reports from 22 human clinical trials and is considered as the most consumer tested Ashwagandha extract. Apart from its impressive test and safety reports the withanolide concentration is only 5%, limiting its potency compared to other Ashwagandha extracts in the market.

Sensoril Ashwagandha

Sensoril is another well researched Ashwagandha root and leaf extract recommended for its role in cognitive support. Derived from the leaves and roots of the Withania somnifera plant, the extraction process utilises water with 10% withanolides concentration. Sensoril also has significant safety data confirmed through 12 published preclinical as well as biomarker studies which were conducted in a wide participant population mainly around stress, sleep management with a 62% reduction in daily everyday stress.

Shoden Ashwagandha

Shoden Ashwagandha is a clinically tested, new and innovative purified Ashwagandha extract having full spectrum of 35% withanolides measured by HPLC, making it a product with highest quantity of enriched and optimised Ashwagandha extracts. Using both roots and leaves for maximum efficacy, Shoden Ashwagandha utilises modern and updated extraction process as well as intensive research utilising an intricate ethanol and water based dual-extraction process. Evaluated in 3 human clinical trials till now, Shoden offer maximised activity at very low doses like 60 mg. Supported by research evidence, Shoden works on a multitude of health benefits like anxiety management and stress relief, sleep cycle restoration, immunomodulation, hormonal balance, cognitive support and positive effects on male vitality.